Domains

REMAP-CAP is flexible: you can choose the domain(s) and interventions (minimum of 2 per domain) you want
to participate in as a site. Each domain is available in one or both of two strata: Non‐pandemic CAP and Pandemic.

Last updated on 25-03-2024

Severe

Moderate

Severe disease state is defined as patients who receive organ failure support in an ICU.

Moderate disease state is defined as:

  • not being admitted to an ICU, or
  • admitted to an ICU but not receiving organ failure support
A

ANTIBIOTICS
Non-pandemic CAP
Pandemic
A.1 – Ceftriaxone + Macrolide
A.2 – Moxifloxacin or Levofloxacin
A.3 – Piperacillin‐Tazobactam + Macrolide
A.5 – Amoxicillin‐Clavulanate + Macrolide

M

Macrolide Duration
Non-pandemic CAP
Pandemic
M.1 – Standard course macrolide
M.2 – Extended course macrolide

C

Corticosteroid
Non-pandemic CAP
Pandemic
C.1 – No corticosteroid
C.3 – Shock‐dependent hydrocortisone
C.5 – Fixed‐course dexamethasone

I

Influenza Antiviral
Non-pandemic CAP
Pandemic
I.1 – No antiviral for influenza
I.2 – Oseltamivir 5 days
I.3 – Oseltamivir 10 days
I.4 – Baloxavir on days 1 and 4
I.5 – 5 days Oseltamivir + Baloxavir on days 1 & 4
I.6 – 10 days Oseltamivir + Baloxavir on days 1 & 4

P

Immunoglobulin
Non-pandemic CAP
Pandemic
P.1 – No immunoglobulin for COVID‐19
P.4 – High‐titer convalescent plasma

V

Mechanical Ventilation
Non-pandemic CAP
Pandemic
V.1 – Clinician‐preferred ventilation strategy
V.2 – Protocolized ventilation strategy

E

Endothelial Modulation
Non-pandemic CAP
Pandemic
E.1 – No endothelial modulator
E.2 – Enteral imatinib

N

Influenza Immune Modulation
Non-pandemic CAP
Pandemic
N.1 No immune modulation (no placebo)
N.2 Tocilizumab
N.3 Baricitinib

* The Influenza Immune Modulation domain in the Netherlands is funded by ZonMw under IMPRINT, dossier no. 10140252210024.

Domain M