Domains

REMAP-CAP is flexible: you can choose the domain(s) and interventions (minimum of 2 per domain) you want
to participate in as a site.

Last updated on 26-08-2021

Severe disease state is defined as patients who require organ support in the ICU.

Moderate disease state is defined as hospitalized patients not receiving organ support.

Domain A

A.1 - IV Ceftriaxone + Macrolide

A.2 - IV Moxifloxacin

A.3 - IV Pip-tazo + Macrolide

A.4 - IV Ceftaroline + Macrolide

A.5 - IV Amoxiclav + Macrolide

ANTIBIOTICS

M.1 - Standard course (3 to 5 days)

M.2 - Extended course (14 days)

Domain M

MACROLIDE
nested within domain A

Domain C

C.1 - No Hydrocortisone (no placebo)

C.2 - IV Hydrocortisone 50 mg every 6 hours for 7 days

C.3 - IV Hydrocortisone 50 mg every 6 hours while in septic shock

CORTICOSTEROID

I.1 - No Oseltamivir (no placebo)

I.2 - 5 days of Oseltamivir

I.2 - 10 days of Oseltamivir

Domain I

INFLUENZA
ANTIVIRAL
Only suspected or proven Influenza as cause of CAP

S.1 - No simvastatin (no placebo)

S.2 - Simvastatin

Domain S

STATIN
THERAPY

Domain D

D.1 No Cysteamine

D.2 Cysteamine

Cysteamine

R.1 - No RAS inhibitor (no placebo)

R.2 - ACE inhibitor

R.3 - ARB

R.4 - ARB + DMX-200

Domain R

H.3 - Conventional low dose thromboprophylaxis (TB) + prior TAC

H.4 - Intermediate dose TB + prior TAC

H.5 - Continuation of therapeutic dose anticoagulation + prior TAC

H.6 - Conventional low dose TB no prior TAC

H.7 - Intermediate dose TB no prior TAC

Domain H

ANTI-COAGULATION

Domain V

V.1 - Clinician preferred

V.2 - Guideline recommended

VENTILATION
Only for patients on invasive mechanical ventilation

B.1 - No antiplatelet (no placebo)

B.2 - Aspirin

B.3 - P2Y12 inhibitor

Domain B

Antiplatelet

Domain
E

E.1 - No endothelial modulator therapy

E.2 - Enteral imatinib

Endothelial Modulation